(This article originally appeared on Bloomberg.com)

The Midwest’s first snow of the season threatens to drop as much as 6 inches (15 centimeters) on Chicago through Saturday.

The storm was coming together Friday over eastern Wyoming and will move east before sweeping up the St. Lawrence River in Canada, where it should die out, said Rob Carolan, a meteorologist with Hometown Forecast Services Inc. in Nashua, New Hampshire. There may be flurries in northern New York State, while Manhattan remains untouched.

“It jets off to the east very quickly,” Carolan said. “A pretty good swath of snow could fall from eastern Nebraska up into Iowa and Michigan.”

This is “the first significant” snowfall across the central U.S., with 4 to 8 inches forecast for a large section of the country from Nebraska to Michigan and even more in some areas, the National Weather Service said. Winter storm warnings, advisories and watches stretch from Idaho to Michigan, including Chicago.

After the storm crosses the Great Lakes, it will start “to fizzle out,” Carolan said. That reduces the threat of any measurable snow in Toronto.

Winter storm and snow-squall watches have been posted by Environment Canada for parts of Ontario bordering lakes Superior and Huron. Toronto could have a mix of rain showers and flurries through Monday. Rain is forecast for Montreal on Sunday.

Carolan said light snow could fall in northern New York and New England from the storm.

The current forecast for next week’s U.S. Thanksgiving holiday calls for mild weather in the East and the potential for some rain along the parts of the West Coast, he said.